Postoperative radiotherapy for gallbladder cancer.

Abstract

AIM:

To evaluate the results of postoperative radiotherapy (PORT) and to identify prognostic factors for gallbladder cancer (GBC).

PATIENTS AND METHODS:

We retrospectively analyzed 86 patients with GBC who underwent potentially curative surgical resection and PORT between November 1993 and December 2009. All patients received three-dimensional conformal radiotherapy and 61 patients (71%) had concurrent chemotherapy. Survival outcomes including locoregional control (LRC), disease-free survival (DFS) and overall survival (OS) rates were analyzed.

RESULTS:

The median follow-up period was 83 months for surviving patients. The 5-year OS, DFS and LRC rates were 42%, 36% and 73%, respectively. Isolated locoregional recurrence as first failure occurred in seven patients (8%). On multivariate analysis, the postoperative carbohydrate antigen 19-9 (CA 19-9) level was a significant prognostic factor for LRC, DFS and OS.

CONCLUSION:

Adjuvant radiotherapy might be an effective treatment in terms of LRC in GBC. Postoperative CA 19-9 might be useful as a surrogate marker for survival.

• Authors: Yuri Jeong, Jin-Hong Park, Young-Joo Lee, Kwang-Min Park, Shin Hwang, Heung-Moon Chang, Kyu-Pyo Kim, Sang Min Yoon, Nuri Hyun Jung, Jong Hoon Kim
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 10 Pg. 5621-9 (Oct 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25275065 (Publication Type: Journal Article)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Follow-Up Studies
• Gallbladder Neoplasms (mortality, radiotherapy, surgery)
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• Radiotherapy, Adjuvant
• Retrospective Studies