Abstract | BACKGROUND: METHODS: Thirty-six 4-month-old female Sprague Dawley rats were randomly assigned to six groups: sham group, ligature group, ovariectomized (OVX) + ligature group, local simvastatin administration to OVX + ligature rats (local simvastatin group), oral simvastatin administration to OVX + ligature rats (oral simvastatin group), local and oral simvastatin administration to OVX + ligature rats (L&O simvastatin group). One month after OVX, ligatures were placed on the maxillary first (M1) and second molars (M2) for 4 weeks on all rats except those in the sham group, followed by simvastatin treatment for 2 months. The maxillae, serum, and femurs were collected for further examination including micro-computed (micro-CT) tomography, hematoxylin and eosin (H&E) staining, tartrate-resistant acid phosphatase (TRAP) staining, enzyme-linked immunosorbent assays (ELISA), and the three-point bending test. RESULTS: Local simvastatin administration increased alveolar crest height and prevented local alveolar bone loss without alteration of systemic bone loss. Oral administration prevented local and systemic bone loss with no effect on alveolar crest height. CONCLUSIONS:
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Authors | Xin-chen Xu, Hui Chen, Xi Zhang, Zan-jing Zhai, Xu-qiang Liu, An Qin, Er-yi Lu |
Journal | Journal of translational medicine
(J Transl Med)
Vol. 12
Pg. 284
(Oct 01 2014)
ISSN: 1479-5876 [Electronic] England |
PMID | 25269614
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Osteocalcin
- Simvastatin
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Topics |
- Alveolar Bone Loss
(diagnostic imaging, drug therapy, etiology, prevention & control)
- Animals
- Biomarkers
(blood)
- Biomechanical Phenomena
(drug effects)
- Cell Count
- Dental Cementum
(drug effects, pathology)
- Dental Enamel
(drug effects, pathology)
- Disease Models, Animal
- Female
- Femur
(drug effects, physiopathology)
- Osteocalcin
(blood)
- Osteoclasts
(drug effects, pathology)
- Osteogenesis
(drug effects)
- Ovariectomy
(adverse effects)
- Periodontitis
(blood, drug therapy, etiology, pathology)
- Rats, Sprague-Dawley
- Simvastatin
(pharmacology, therapeutic use)
- X-Ray Microtomography
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