Treatment of pseudoepitheliomatous, keratotic, and micaceous balanitis with topical photodynamic therapy.

Abstract

BACKGROUND:

Pseudoepitheliomatous, keratotic, and micaceous balanitis (PKMB) is an extremely rare condition occurring over the glans in older men who undergo circumcision late in life. Its exact etiology is unknown.

OBJECTIVES:

We report a patient with PKMB that involved the meatus and led to urinary obstruction.

METHODS:

A 57-year-old, circumcised man presented with partial urinary obstruction caused by a thick, nail-like covering on the skin of his glans penis. Based on histology, PKMB was diagnosed. There was no cytological atypia. The patient was treated successfully with topical 5-aminolevulinic acid (ALA) photodynamic therapy (PDT).

RESULTS:

There was no recurrence after 18 months of follow-up. Treatment with ALA-PDT seems to be effective and well tolerated in PKMB.

CONCLUSIONS:

This case indicates that ALA-PDT may be an effective treatment option for plaque-stage PKMB and thus warrants further investigation.

• Authors: Hui Zhu, Yong Jiang, Matthew Watts, Fanrong Kong
• Journal: International journal of dermatology (Int J Dermatol) Vol. 54 Issue 2 Pg. 245-7 (Feb 2015) ISSN: 1365-4632 [Electronic] England
• PMID: 25266766 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 The International Society of Dermatology.

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Aminolevulinic Acid (therapeutic use)
• Balanitis (drug therapy, pathology)
• Humans
• Male
• Middle Aged
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)