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Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases.

Abstract
Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately.
AuthorsS Farough, A Karaa, M A Walker, N Slate, T Dasu, J Verbsky, R Fusunyan, C Canapari, T B Kinane, J Van Cleave, D A Sweetser, K B Sims, J E Walter
JournalClinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 155 Issue 2 Pg. 209-12 (Dec 2014) ISSN: 1521-7035 [Electronic] United States
PMID25264263 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2014 Elsevier Inc. All rights reserved.
Chemical References
  • Immunoglobulin G
  • Ubiquinone
  • coenzyme Q10
Topics
  • Ataxia (diagnosis, drug therapy, immunology, metabolism)
  • Child, Preschool
  • Enzyme Replacement Therapy
  • Female
  • Humans
  • Immunity (physiology)
  • Immunoglobulin G (blood, immunology)
  • Lymphocyte Subsets (immunology, metabolism)
  • Mitochondrial Diseases (diagnosis, drug therapy, immunology, metabolism)
  • Muscle Weakness (diagnosis, drug therapy, immunology, metabolism)
  • Treatment Outcome
  • Ubiquinone (analogs & derivatives, deficiency, immunology, metabolism, therapeutic use)

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