Abstract | BACKGROUND: OBJECTIVES: METHODS: Community- and worker-cohort participants completed surveys during 2008-2011 covering demographics, health-related behaviors, and medical history. Cox proportional hazard models, stratified by birth year, modeled the hazard of each outcome (starting at 20 years of age) as a function of retrospective serum PFOA concentration estimates (generated through fate, transport and exposure modeling), controlling for sex, race, education, smoking, alcohol use, body mass index, and diabetes. RESULTS: Among 32,254 participants (28,541 community; 3,713 worker), 12,325 reported hypertension with medication, 9,909 reported hypercholesterolemia with medication, and 3,147 reported coronary artery disease (2,550 validated). Hypercholesterolemia incidence increased with increasing cumulative PFOA exposure (sum of yearly serum concentration estimates), most notably among males 40-60 years of age. Compared with the lowest exposure quintile (< 142 ng/mL-years), hazard ratios for subsequent quintiles (ng/mL-years: 142 to < 234; 234 to < 630; 630 to < 3,579; ≥ 3,579) were 1.24, 1.17, 1.19, and 1.19 overall and 1.38, 1.32, 1.31, and 1.44 among men 40-60 years of age. There was no apparent association between PFOA exposure and hypertension or coronary artery disease incidence. CONCLUSIONS:
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Authors | Andrea Winquist, Kyle Steenland |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 122
Issue 12
Pg. 1299-305
(Dec 2014)
ISSN: 1552-9924 [Electronic] United States |
PMID | 25260175
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Air Pollutants
- Caprylates
- Fluorocarbons
- perfluorooctanoic acid
- Cholesterol
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Topics |
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Air Pollutants
(adverse effects)
- Caprylates
(adverse effects)
- Cholesterol
(blood)
- Cohort Studies
- Coronary Artery Disease
(blood, chemically induced, epidemiology)
- Cross-Sectional Studies
- Employment
- Environmental Exposure
(adverse effects)
- Female
- Fluorocarbons
(adverse effects)
- Georgia
(epidemiology)
- Humans
- Hypertension
(blood, chemically induced, epidemiology)
- Male
- Middle Aged
- Occupational Diseases
(blood, chemically induced, epidemiology)
- Residence Characteristics
- Sex Factors
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