Effects of basic fibroblast growth factor dose on traumatic tympanic membrane perforation.

Abstract

OBJECTIVE:

To compare the healing outcomes of higher and lower doses of basic fibroblast growth factor (bFGF) on human traumatic tympanic membrane perforation (TMP).

STUDY DESIGN:

Prospective clinical study.

METHODS:

All patients with traumatic TMP were treated by direct application of bFGF, and were sequentially allocated into one of two groups: lower-dose group (2-3 drops of bFGF solution daily, approximately 0.1-0.15 mL) and higher-dose group (5-6 drops of bFGF solution daily, approximately 0.25-0.3 mL). The results of closure rate, closure time, and rate of otorrhea between the higher- and lower-dose groups were compared at 3 months.

RESULTS:

In total, 126 patients were included in this study. The higher-dose group showed significantly improved purulent otorrhea rate compared with the lower-dose group (p < 0.01) for perforations of the same size, although the closure rate of the middle-sized perforations did not differ significantly between higher- and lower-dose groups (p > 0.05). However, the lower-dose group had a significantly shorter closure time of 5 d compared with the higher-dose group (p < 0.05). In addition, although the lower-dose group showed shorter healing times (about 3 d) compared to the higher-dose group for large-sized perforations, the dosage of bFGF did not significantly affect the large-sized perforation closure rate (p > 0.05) or closure time (p > 0.05). Nine large-sized perforations with secondary purulent otorrhea achieved complete closure, with closure times of 7-25 (14.2 ± 5.8) d.

CONCLUSION:

This study suggested that continued daily application of a lower dose of bFGF not only shortens the closure time of human traumatic TMP but also avoids secondary purulent otorrhea.

• Authors: Zhengcai Lou, Yubizhuo Wang, Guoning Yu
• Journal: Growth factors (Chur, Switzerland) (Growth Factors) Vol. 32 Issue 5 Pg. 150-4 (Oct 2014) ISSN: 1029-2292 [Electronic] England
• PMID: 25257249 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Fibroblast Growth Factor 2
• Amoxicillin

Topics

• Adolescent
• Adult
• Amoxicillin (administration & dosage)
• Cell Proliferation
• Female
• Fibroblast Growth Factor 2 (administration & dosage, therapeutic use)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Prospective Studies
• Treatment Outcome
• Tympanic Membrane (drug effects)
• Tympanic Membrane Perforation (drug therapy)
• Wound Healing
• Young Adult