Managing menorrhagia in a familial case of factor V deficiency.

Factor V deficiency is a rare coagulation disorder. Excessive uterine bleeding is common in affected women. We describe a case of 2 siblings with Factor V deficiency and menorrhagia who achieved control of bleeding with differing treatments.
Patient 1 is a 16-year-old female with Factor V deficiency and menorrhagia which was previously controlled with oral contraceptives (OC). She developed heavy bleeding treated with fresh frozen plasma, anti-inhibitor coagulant complex (AICC), and OC taper. A levonorgestrel IUD was placed with good control of her menorrhagia. Patient 2 is the 12-year-old sister of Patient 1. She was treated with AICC, aminocaproic acid, and her menorrhagia was ultimately controlled with continuous OCs.
Factor V deficiency is a rare cause of menorrhagia. Various treatment modalities are available. In these adolescent sisters desiring future fertility, menorrhagia was managed with OCs and an IUD.
AuthorsM Stalnaker, P Esquivel
JournalJournal of pediatric and adolescent gynecology (J Pediatr Adolesc Gynecol) Vol. 28 Issue 1 Pg. e9-12 (Feb 2015) ISSN: 1873-4332 [Electronic] United States
PMID25256869 (Publication Type: Journal Article)
CopyrightCopyright © 2015 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

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