Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: MATERIALS AND METHODS: RESULTS AND CONCLUSIONS: PEE (120mg/kg bw per day) efficiently attenuated the severity of arthritis in the CIA rats by reducing the mean arthritis severity scores and the fore/hind paw swelling as well as reduced histological changes by decreasing the cartilage surface erosion and cartilage proteoglan depletion. PEE׳s therapeutic effect in RA may involve the inhibition of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in serum and/or the elevation of the activities of hepatic anti-oxidative enzymes including SOD, CAT and GSH-Px. However, the detailed anti-inflammatory mechanism, the main effective components and the interaction between different ingredients in PEE are still not clear and require more studies.
|
Authors | Jianhong Wu, Xingxian Liu, Chi-on Chan, Daniel K W Mok, Shun-wan Chan, Zhiling Yu, Sibao Chen |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 157
Pg. 45-54
(Nov 18 2014)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 25256690
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Alkanes
- Anti-Inflammatory Agents
- Collagen Type II
- Plant Extracts
- lei gong teng
- Dexamethasone
- naphtha
|
Topics |
- Alkanes
(chemistry)
- Animals
- Anti-Inflammatory Agents
(administration & dosage, isolation & purification, pharmacology)
- Arthritis, Experimental
(drug therapy, pathology)
- Arthritis, Rheumatoid
(drug therapy, pathology)
- Cattle
- Collagen Type II
(toxicity)
- Dexamethasone
(pharmacology)
- Dose-Response Relationship, Drug
- Male
- Plant Extracts
(administration & dosage, pharmacology)
- Rats
- Rats, Wistar
- Rosa
(chemistry)
- Severity of Illness Index
|