Abstract | OBJECTIVE: METHODS: In a cohort of patients with hip OA who underwent a primary elective THA between 2002 and 2009, we identified those who received ≥1 intraarticular injection performed by a radiologist in the 5 years preceding their THA. Multivariable Cox proportional hazards models were used to determine the relationship between receipt of a presurgical injection (no injection, 1-5 years prior to THA, or <1 year prior to THA) and the occurrence of postsurgical joint infection and revision THA in the following 2 years, while controlling for confounders. RESULTS: Of 37,881 eligible THA recipients, 2,468 (6.5%) received an intraarticular injection performed by a radiologist within 5 years of their THA (1,691 at <1 year, 777 at 1-5 years). Controlling for age, sex, comorbidity, frailty, income, and provider volume, those who had an injection in the year preceding surgery were at increased risk of infection (adjusted hazard ratio [HR] 1.37, P = 0.03) and revision THA (adjusted HR 1.53, P = 0.03) within 2 years of the primary THA, relative to patients who did not. The association between prior injection and revision arthroplasty was attenuated and became nonsignificant (adjusted HR 1.41, P = 0.13) after occurrence of postoperative infection was controlled for in the regression model. No effect was found for injection 1-5 years prior to surgery. CONCLUSION:
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Authors | Bheeshma Ravi, Benjamin G Escott, David Wasserstein, Ruth Croxford, Simon Hollands, J Michael Paterson, Hans J Kreder, Gillian A Hawker |
Journal | Arthritis & rheumatology (Hoboken, N.J.)
(Arthritis Rheumatol)
Vol. 67
Issue 1
Pg. 162-8
(Jan 2015)
ISSN: 2326-5205 [Electronic] United States |
PMID | 25250699
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 by the American College of Rheumatology. |
Chemical References |
- Adrenal Cortex Hormones
- Hyaluronic Acid
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Aged
- Arthroplasty, Replacement, Hip
- Bacterial Infections
(epidemiology)
- Cohort Studies
- Female
- Hip Joint
(microbiology, surgery)
- Humans
- Hyaluronic Acid
(administration & dosage, therapeutic use)
- Injections, Intra-Articular
(adverse effects)
- Male
- Middle Aged
- Ontario
- Osteoarthritis, Hip
(therapy)
- Postoperative Complications
(epidemiology)
- Postoperative Period
- Preoperative Period
- Proportional Hazards Models
- Reoperation
- Retrospective Studies
- Risk Factors
- Treatment Outcome
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