Abstract | INTRODUCTION:
Melatonin is a hormone which is known to be a powerful cardioprotective agent due to its free radical-scavenging properties. This study was carried out to evaluate whether melatonin administration prior to irradiation would have a protective effect on cardiac histopathological changes in an experimental rat model. METHODS: Rats were divided into four groups. Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. 50mg/kg dose of melatonin were injected intraperitonally 15 min prior to radiation exposure. Analyses and assessments were performed 6 months after radiation exposure. RESULTS: Severe myocardial fibrosis was observed prominently in three regions: the apex, tips of papillary muscles and adjacent to the atrioventricular valves. Inflammation was found to be more in irradiated groups. Increased inflammation and fibrosis were in concordance. The number of mast cells was found to be decreased in irradiated groups. Myocyte necrosis and fibrosis were diminished with melatonin while vasculitis was prevented. CONCLUSIONS:
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Authors | Iclal Gürses, Murat Özeren, Meltem Serin, Neslihan Yücel, Haldun Şükrü Erkal |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 210
Issue 12
Pg. 863-71
(Dec 2014)
ISSN: 1618-0631 [Electronic] Germany |
PMID | 25249491
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier GmbH. All rights reserved. |
Chemical References |
- Radiation-Protective Agents
- Melatonin
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Topics |
- Animals
- Cardiomyopathies
(etiology, pathology, prevention & control)
- Coronary Artery Disease
(etiology, pathology, prevention & control)
- Coronary Vessels
(drug effects, pathology, radiation effects)
- Cytoprotection
- Fibrosis
- Male
- Mast Cells
(drug effects, pathology, radiation effects)
- Melatonin
(pharmacology)
- Myocarditis
(etiology, pathology, prevention & control)
- Myocytes, Cardiac
(drug effects, pathology, radiation effects)
- Necrosis
- Radiation Injuries, Experimental
(pathology, prevention & control)
- Radiation-Protective Agents
(pharmacology)
- Rats, Wistar
- Time Factors
- Vasculitis
(etiology, pathology, prevention & control)
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