[A case of gastric cancer that responded to a preoperative combination therapy of S-1/CDDP plus trastuzumab].

Abstract

A 79-year-old man was diagnosed with advanced gastric cancer (cT3, N1, M0, cStage II B) showing regional bulky lymph node metastasis. Invasion of the pancreas and common hepatic artery was suspected. He was treated with S-1/CDDP plus trastuzumab therapy as a neoadjuvant chemotherapy (NAC) regimen. After two courses, significant tumor reduction was observed, and the patient underwent distal gastrectomy with D2 dissection. S-1/CDDP plus trastuzumab therapy as NAC for HER2-positive, advanced gastric cancer appears to be an effective treatment.

• Authors: Satoshi Sueoka, Akihiro Ito, Jun Kawanishi, Yoshikazu Sakakima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 9 Pg. 1155-7 (Sep 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25248902 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Trastuzumab
• Cisplatin

Topics

• Aged
• Antibodies, Monoclonal, Humanized (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Drug Combinations
• Gastrectomy
• Humans
• Male
• Neoadjuvant Therapy
• Neoplasm Staging
• Oxonic Acid (administration & dosage)
• Stomach Neoplasms (drug therapy, pathology)
• Tegafur (administration & dosage)
• Trastuzumab