Abstract | OBJECTIVE: We evaluated the effect of close contact between the stent and the graft on the induction of endothelial covering on the stent graft placed over an aneurysm. MATERIALS AND METHODS: RESULTS: The animals were sacrificed at two (n = 3), six (n = 3), and eight months (n = 2) after endovascular repair. In two dogs, the aortic lumen was occluded at two months after the placement. On gross inspection of specimens from the other six dogs with a patent aortic lumen, stent grafts placed over the normal aortic wall were covered by glossy white neointima, whereas, stent grafts placed over the aneurysmal aortic wall were covered by brownish neointima. On microscopic inspection, stent grafts placed over the normal aortic wall were covered by thin neointima (0.27 ± 0.05 mm, mean ± standard deviation) with an endothelial layer, and stent grafts placed over the aneurysmal aortic wall were covered by thick neointima (0.62 ± 0.17 mm) without any endothelial lining. Transgraft cell migration at the normal aortic wall was more active than that at the aneurysmal aortic wall. CONCLUSION: Close contact between the stent and the graft, which was achieved with stent grafts with endo-exo-skeleton, could not enhance endothelial covering on the stent graft placed over the aneurysms.
|
Authors | Young Il Kim, Young Ho Choi, Jin Wook Chung, Hyo-Cheol Kim, Young Ho So, Hyun Beom Kim, Seung-Kee Min, Jae Hyung Park |
Journal | Korean journal of radiology
(Korean J Radiol)
2014 Sep-Oct
Vol. 15
Issue 5
Pg. 622-9
ISSN: 2005-8330 [Electronic] Korea (South) |
PMID | 25246823
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Animals
- Aortic Aneurysm, Abdominal
(pathology, therapy)
- Blood Vessel Prosthesis Implantation
- Disease Models, Animal
- Dogs
- Endothelium, Vascular
(cytology, pathology)
- Stents
- Tomography, X-Ray Computed
|