Abstract | PURPOSE: Although placental abruption is an acute condition, it is thought that the underlying pathology is chronic vasculopathy. Collagen is one of the important components of vascular structure, and there is a correlation between collagen turnover and prolidase enzyme activity (PEA). Thus, our aim was to assess whether there is a difference in serum oxidative stress level and PEA between pregnant women with placental abruption and those with a healthy pregnancy. METHODS: RESULTS: No significant differences in demographic characteristics were detected between groups (p > 0.05). Oxidative stress parameters, such as total oxidant status and oxidative stress index, were found to be significantly higher in the study group (p < 0.001). Placental tissue PEA was found to be significantly higher in pregnant women with placental abruption (557.21 ± 135.41 vs. 426.68 ± 131.57 U/g, p < 0.001). In addition, a significant positive correlation was detected between PEA and oxidative stress parameters (r = 0.332, p = 0.004). CONCLUSIONS: Our results indicated that elevated tissue PEA and serum oxidative stress levels are closely related to placental abruption. Thus, we think that increased collagen turnover may have a significant role in the aetiopathogenesis of placental abruption.
|
Authors | Adnan Incebiyik, Mehmet Vural, Aysun Camuzcuoglu, Hakan Camuzcuoglu, Nese Gul Hilali, Abdullah Taskin, Halef Aydin, Nurten Aksoy |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 291
Issue 4
Pg. 805-9
(Apr 2015)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 25241274
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Dipeptidases
- proline dipeptidase
|
Topics |
- Abruptio Placentae
(blood, etiology)
- Adult
- Case-Control Studies
- Cesarean Section
(adverse effects)
- Dipeptidases
(blood, metabolism)
- Female
- Humans
- Oxidative Stress
(physiology)
- Placenta
(enzymology, metabolism)
- Pregnancy
- Pregnancy Complications
(blood)
|