The relationship between the level of serum 25-hydroxyvitamin D and renal function in patients without chronic kidney disease: a cross-sectional study.

Abstract

OBJECTIVES:

Low level of vitamin D has been suggested as a risk factor for chronic kidney disease (CKD). However, little is known about the effect of vitamin D on renal function in healthy subjects. Our aim was to investigate the question of whether vitamin D status is associated with renal function in subjects without CKD.

METHODS:

In this cross-sectional study, 1,648 subjects aged older than 20 years were recruited as study participants. Subjects diagnosed with either CKD or other conditions that could influence serum vitamin D were excluded. Estimated glomerular filtration rate (eGFR) from serum creatinine (sCr) was used for the determination of renal function. Vitamin D status was determined by the measurement of serum 25-hydroxyvitamin D [25(OH)D] levels.

RESULTS:

In men, 25(OH)D showed significant positive correlation with age (r = 0.127, P < .001), skeletal muscle mass (r = 0.077, P = .017), sCr (r = 0.128, P < .001), and negative correlation with body fat (r = -0.065, P = .044), eGFR (r = -0.152, P < .001). In women, 25(OH)D showed negative correlation with eGFR (r = -0.085, P = .026), but not with age and body composition. In multiple linear regression analysis, 25(OH)D (β = 0.114, P < .001), total muscle mass (β = 0.202, P = .026), and age (β = 0.117, P = .003) were an independent determinant of sCr in men; in women, 25(OH)D (β = 0.086, P = .023), total muscle mass (β = 0.152, P < .001) were variables showing significant association with sCr.

CONCLUSIONS:

Higher level of 25(OH)D is independently associated with sCr elevation. We suggest that a positive correlation between 25(OH)D and muscle mass could be attributed to sCr. It is thought to be another mechanism of serum 25(OH)D level in renal function in populations without CKD.

• Authors: Young Jin Tak, Jeong Gyu Lee, Sang Heon Song, Yun Jin Kim, Sangyeoup Lee, Dong Wook Jung, Yu Hyeon Yi, Young Hye Cho, Eun Jung Choi, Hye Rim Hwang
• Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (J Ren Nutr) Vol. 25 Issue 2 Pg. 88-96 (Mar 2015) ISSN: 1532-8503 [Electronic] United States
• PMID: 25238696 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Age Factors
• Cross-Sectional Studies
• Female
• Glomerular Filtration Rate (physiology)
• Humans
• Kidney (physiology)
• Male
• Middle Aged
• Risk Factors
• Sex Factors
• Vitamin D (analogs & derivatives, blood)