Super-resolution reconstruction of late gadolinium-enhanced MRI for improved myocardial scar assessment.

Abstract

PURPOSE:

To develop and validate a method for improving image resolution of late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) for accurate assessment of myocardial scar.

MATERIALS AND METHODS:

In a cohort of 37 postinfarction patients, LGE was performed prior to ventricular tachycardia catheter ablation therapy at 1.5T. A super-resolution reconstruction (SRR) technique was applied to the three anisotropic views: short-axis (SA), two-chamber, and four-chamber, to reconstruct a single isotropic volume. For compensation of the interscan heart motion, a joint localized gradient-correlation-based scheme was developed. Scar was identified as either core or gray zone in both the SRR and original SA volumes, and evaluated based on the clinically established bipolar voltage range of the in vivo electroanatomical voltage mapping (EAVM).

RESULTS:

Compared to the SA volume, the SRR method resulted in significantly (P < 0.05) reduced myocardial scar gray zone sizes (10.5 ± 8.8 g vs. 9.2 ± 8.1 g) and improved agreement of the bipolar voltage range of scar gray zone (0.99 ± 0.65 mV vs. 1.46 ± 1.15 mV).

CONCLUSION:

We propose an SRR method to automatically reconstruct a high-quality isotropic LGE volume from three orthogonal views. Analysis of the in vivo EAVM demonstrated improved myocardial scar assessment from the SRR volume compared with the SA LGE alone.

• Authors: Oleh Dzyubachyk, Qian Tao, Dirk H J Poot, Hildo J Lamb, Katja Zeppenfeld, Boudewijn P F Lelieveldt, Rob J van der Geest
• Journal: Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 42 Issue 1 Pg. 160-7 (Jul 2015) ISSN: 1522-2586 [Electronic] United States
• PMID: 25236764 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Contrast Media
• Gadolinium DTPA

Topics

• Cicatrix (pathology)
• Contrast Media (administration & dosage)
• Female
• Gadolinium DTPA (administration & dosage)
• Humans
• Image Enhancement (methods)
• Image Interpretation, Computer-Assisted (methods)
• Imaging, Three-Dimensional (methods)
• Male
• Middle Aged
• Myocardial Stunning (pathology)
• Reproducibility of Results
• Sensitivity and Specificity