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Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol.

Abstract
The present study (i) compared plasma cholesterol-raising activity of free cholesterol (FC) with that of cholesteryl palmitate (CP) and (ii) examined plasma cholesterol-reducing activity of β-sitosterol in FC-induced and CP-induced hypercholesterolemia. Male hamsters were divided into five groups and fed one of the five diets containing no cholesterol (NC), 2.6mmol cholesterol (C), 2.6mmol cholesterol plus 2.6mmol β-sitosterol (C+S), 2.6mmol cholesteryl palmitate (CP), and 2.6mmol CP plus 2.6mmol β-sitosterol (CP+S), respectively, for 8weeks. Hamsters fed diet C had plasma TC of 317.5mg/dl whereas hamsters fed diet CP has plasma TC of 281.3mg/dl. β-Sitosterol reduced plasma TC by 17.4% and 11.6%, respectively, in FC-induced and CP-induced hypercholesterolemia (not significant). It was concluded that plasma cholesterol-raising activity of dietary cholesterol was a function of its chemical forms in diet, and β-sitosterol could similarly suppress the hypercholesterolemia induced by both dietary FC and CP.
AuthorsYuwei Liu, Lin Lei, Xiaobo Wang, Ka Ying Ma, Yuk Man Li, Lijun Wang, Sun Wa Man, Yu Huang, Zhen-Yu Chen
JournalFood chemistry (Food Chem) Vol. 169 Pg. 277-82 (Feb 15 2015) ISSN: 1873-7072 [Electronic] England
PMID25236227 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Cholesterol Esters
  • Cholesterol, Dietary
  • Cholesterol, HDL
  • Sitosterols
  • Triglycerides
  • gamma-sitosterol
  • cholesteryl palmitate
Topics
  • Animals
  • Cholesterol Esters (pharmacology)
  • Cholesterol, Dietary (pharmacology)
  • Cholesterol, HDL (blood)
  • Cricetinae
  • Feces (chemistry)
  • Hypercholesterolemia (etiology, prevention & control)
  • Liver (metabolism)
  • Male
  • Mesocricetus
  • Sitosterols (pharmacology)
  • Triglycerides (blood)

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