Abstract | OBJECTIVE: METHODS: In this cross-sectional study, all consecutive patients with acute dyspnea underwent clinical evaluation, laboratory assessment of NT-proBNP, and echocardiographic examinations. Among subjects, 54.5% were diagnosed as heart failure. Grouping variables according to renal function capacity and ejection fraction, independent variables were compared with Kruskal-Wallis or ANOVA with posthoc tests. Correlation and linear regression analysis were done to analyze the variables associated with NT-proBNP. The diagnostic performance of NT-proBNP was evaluated by receiver-operating characteristic (ROC) curve. RESULTS: Serum median NT-proBNP level in patients with severe renal impairment was significantly higher than moderate and mildly decreased renal functions (p=0.001). In patients with moderate and severe left ventricular failure, NT-proBNP was significantly higher compared with normal subjects (LVEF>50%) (p=0.040, and 0.017, respectively). Renal dysfunction was associated in 56% of patients with heart failure. The area under the ROC curve of NT-proBNP for identifying left ventricular failure in patients with renal failure (eGFR<90 mL/min/1.73 m2) was 0.649 and reached significant difference (95% CI:0.548-0.749, p=0.005). CONCLUSION: In addition to NT-proBNP measurement in clinical judgement of heart failure, renal functions have to be taken into consideration to avoid misdiagnosis.
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Authors | Ayfer Çolak, Serap Çuhadar, Burcu Gölcük, Yalçin Gölcük, Öner Özdoğan, Işil Çoker |
Journal | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
(Anadolu Kardiyol Derg)
Vol. 14
Issue 6
Pg. 519-24
(Sep 2014)
ISSN: 1308-0032 [Electronic] Turkey |
PMID | 25233498
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Biomarkers
(blood)
- Cross-Sectional Studies
- Dyspnea
(etiology)
- Echocardiography
- Emergency Service, Hospital
- Female
- Heart Failure
(blood, complications, diagnosis, diagnostic imaging)
- Humans
- Male
- Natriuretic Peptide, Brain
(blood)
- Patient Admission
- Peptide Fragments
(blood)
- Predictive Value of Tests
- ROC Curve
- Renal Insufficiency
(blood, complications)
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