Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.

Abstract	The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.
Authors	M B Datiles 3rd, H Fukui
Journal	Current eye research (Curr Eye Res) Vol. 8 Issue 3 Pg. 233-7 (Mar 1989) ISSN: 0271-3683 [Print] England
PMID	2523284 (Publication Type: Journal Article)
Chemical References	Imidazoles Imidazolidines Streptozocin Sugar Alcohol Dehydrogenases Aldehyde Reductase sorbinil
Topics	Aldehyde Reductase (antagonists & inhibitors) Animals Cataract (etiology, pathology, prevention & control) Diabetes Mellitus, Experimental (complications, pathology) Disease Models, Animal Imidazoles (therapeutic use) Imidazolidines Lens, Crystalline (pathology) Rodentia (physiology) Streptozocin Sugar Alcohol Dehydrogenases (antagonists & inhibitors)

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