Association of antimüllerian hormone levels with menstrual-cycle type and dysmenorrhea in young asymptomatic women.

Abstract

OBJECTIVE:

To examine the association between antimüllerian hormone (AMH) levels and menstrual-cycle and lifestyle characteristics among young Japanese women.

DESIGN:

Cross-sectional study.

SETTING:

University.

PATIENT(S):

Female students aged 20-22 years (n=65) who had never used oral contraceptives.

INTERVENTION(S):

Participants completed a questionnaire on reproductive and lifestyle characteristics, and kept a menstrual-cycle diary for 5 consecutive months. Serum AMH was measured once during the study period.

MAIN OUTCOME MEASURE(S):

Serum AMH concentration.

RESULT(S):

Compared with women with very mild menstrual pain, serum AMH concentration was 49.6% (95% CI 6.5%-72.8%) lower among women with severe menstrual pain. Higher AMH concentration was associated with irregular menstrual cycles. Even after adjusting for menstrual-cycle regularity and its interaction, more-severe menstrual pain was associated with significantly lower AMH concentration.

CONCLUSION(S):

Circulating AMH concentration was significantly lower among young Japanese women who had more-severe menstrual pain. Underlying physiological mechanisms need to be addressed in future studies.

• Authors: Shoko Konishi, Yukiko Nishihama, Ayaka Iida, Jun Yoshinaga, Hideki Imai
• Journal: Fertility and sterility (Fertil Steril) Vol. 102 Issue 5 Pg. 1439-43 (Nov 2014) ISSN: 1556-5653 [Electronic] United States
• PMID: 25226856 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Anti-Mullerian Hormone

Topics

• Anti-Mullerian Hormone (blood)
• Asymptomatic Diseases
• Biomarkers (blood)
• Dysmenorrhea (blood, diagnosis)
• Female
• Humans
• Menstrual Cycle (blood)
• Reproducibility of Results
• Sensitivity and Specificity
• Young Adult