Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis.

Abstract

The aim of this study was to explore the association between follicle stimulating hormone receptor (FSHR) Thr307Ala and Asn680Ser polymorphisms and susceptibility to polycystic ovary syndrome (PCOS). A comprehensive literature search for relevant studies was conducted on Google Scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Ten case-control studies were included in this meta-analysis. However, meta-analysis results showed no association between both FSHR Thr307Ala polymorphism and Asn680Ser polymorphism and susceptibility to PCOS. Stratified analysis of ethnicities also showed no association. In conclusion, the present study suggested that the FSHR polymorphisms were not associated with an increased risk of PCOS and larger-scale studies of populations are needed to explore the roles played by FSHR polymorphisms during the pathogenesis of PCOS.

• Authors: Dao-Jun Chen, Rui Ding, Ji-Yu Cao, Jin-Xia Zhai, Jia-Xiang Zhang, Dong-Qing Ye
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 182 Pg. 27-32 (Nov 2014) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 25218548 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Receptors, FSH

Topics

• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Humans
• Polycystic Ovary Syndrome (ethnology, genetics)
• Polymorphism, Genetic
• Receptors, FSH (genetics)
• Risk Factors