Abstract | AIM: METHODS: The levels of homocysteine, ADMA, and NO and activity of eNOS in patients who were diagnosed with wet AMD by fundus fluorescein angiography ( n=30) were compared to a control group with no retinal pathology ( n=30). RESULTS: Levels of homocysteine and ADMA were found to be significantly higher in the wet AMD group than in the control group (P<0.001), whereas NO levels and eNOS activity were higher in the control group (P<0.001). In the wet AMD group, we detected a 2.64- and 0.33-fold increase in the levels of ADMA and homocysteine, respectively, and a 0.49- and 2.41-fold decrease in the eNOS activity and NO level, respectively. CONCLUSION: Elevated levels of homocysteine and ADMA were observed in patients with wet AMD. Increased ADMA may be responsible for the diminished eNOS activity found in these patients, which in turn contributes to the decrease in NO levels, which likely plays a role in the pathogenesis of AMD.
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Authors | Sadullah Keles, Orhan Ates, Baki Kartal, Hamit Hakan Alp, Metin Ekinci, Erdinc Ceylan, Osman Ondas, Eren Arpali, Semih Dogan, Kenan Yildirim, Mevlut Sait Keles |
Journal | Clinical ophthalmology (Auckland, N.Z.)
(Clin Ophthalmol)
Vol. 8
Pg. 1573-8
( 2014)
ISSN: 1177-5467 [Print] New Zealand |
PMID | 25210424
(Publication Type: Journal Article)
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