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3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia.

Abstract
3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits.
AuthorsWanhong Zhao, Chao Luo, Jue Wang, Jian Gong, Bin Li, Yingxia Gong, Jun Wang, Hanqin Wang
JournalNeural regeneration research (Neural Regen Res) Vol. 9 Issue 7 Pg. 719-26 (Apr 01 2014) ISSN: 1673-5374 [Print] India
PMID25206879 (Publication Type: Journal Article, Review)

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