S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.

Abstract

Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses. The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exerting a neu-roprotective effect on hippocampal neurons.

• Authors: Xue Li, Wencong Zhao, Hongqi Yang, Junhong Zhang, Jianjun Ma
• Journal: Neural regeneration research (Neural Regen Res) Vol. 8 Issue 27 Pg. 2573-80 (Sep 25 2013) ISSN: 1673-5374 [Print] India
• PMID: 25206568 (Publication Type: Journal Article)