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Decline in lymphatic filariasis transmission with annual mass drug administration using DEC with and without albendazole over a 10year period in India.

Abstract
The National Programme for the Elimination of Lymphatic Filariasis is underway in the endemic districts of Tamil Nadu State, South India, since 2001. Annual mass drug administration (MDA) was carried out by the state health department to all eligible individuals. The impact of MDAs on transmission parameters was evaluated in 2 revenue blocks, viz, one with DEC alone and the other with a combination of albendazole. After 10 years with 6 annual MDAs, the transmission indices reached low levels in both treatment arms, but still persisted. However, the DEC alone arm showed higher transmission rates, compared to the DEC+ALB arm. Few villages which demonstrated persistent transmission need to be targeted with an additional control measure viz, vector control, to achieve LF elimination. It is evident from the 10 year period of the study that inclusion of albendazole along with DEC has significantly reduced the transmission indices to almost nil level, as compared to DEC alone.
AuthorsI P Sunish, M Kalimuthu, R Rajendran, A Munirathinam, V Ashok Kumar, J Nagaraj, B K Tyagi
JournalParasitology international (Parasitol Int) Vol. 64 Issue 1 Pg. 1-4 (Feb 2015) ISSN: 1873-0329 [Electronic] Netherlands
PMID25205435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Filaricides
  • Albendazole
  • Diethylcarbamazine
Topics
  • Albendazole (administration & dosage, therapeutic use)
  • Animals
  • Culex (parasitology)
  • Diethylcarbamazine (administration & dosage, therapeutic use)
  • Disease Eradication
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Elephantiasis, Filarial (drug therapy, prevention & control, transmission)
  • Filaricides (administration & dosage, therapeutic use)
  • Humans
  • India (epidemiology)
  • Insect Vectors (parasitology)
  • Longitudinal Studies
  • Treatment Outcome

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