Abstract | HISTORY AND CLINICAL FINDINGS: A 49-year-old, otherwise healthy man presented at his dermatologist with tuberous skin changes that had be present for several weeks on head, arm and leg. These were asymptomatic, but disturbed him cosmetically. A skin biopsy was performed. INVESTIGATIONS: The skin biopsy showed a granulomatous inflammation with prominent plasma cells, consistent with granulomatous infiltrate. Serologic tests confirmed a Treponema pallidum- infection. In addition, the patient was tested positive for hepatitis C and HIV (CDC stage A1). The clinical neurological examination did not show any pathological findings, however, analysis of the cerebrospinal fluid revealed a mild pleocytosis, elevation of protein and the glucose quotient and a normal Treponema pallidum TPPA-antibody index. A mesaortitis was excluded. THERAPY AND COURSE: CONCLUSIONS: In view of the increasing incidence of syphilis in Germany clinicians should consider this diagnosis when confronted with oligosymptomatic skin lesions.
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Authors | C Schummer, S Schliemann, V Fünfstück, P Elsner |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 139
Issue 38
Pg. 1883-6
(Sep 2014)
ISSN: 1439-4413 [Electronic] Germany |
Vernacular Title | Hautmanifestation bei Spätsyphilis. |
PMID | 25203547
(Publication Type: Case Reports, English Abstract, Journal Article)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
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Topics |
- Administration, Oral
- Biopsy
- Ceftriaxone
(administration & dosage)
- Comorbidity
- Diagnosis, Differential
- Drug Therapy, Combination
- HIV Seropositivity
(diagnosis, pathology)
- Hepatitis C, Chronic
(diagnosis, pathology)
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Neurosyphilis
(diagnosis, drug therapy, pathology)
- Prednisolone
(administration & dosage)
- Skin
(pathology)
- Syphilis
(diagnosis, drug therapy, pathology)
- Syphilis Serodiagnosis
- Syphilis, Cutaneous
(diagnosis, drug therapy, pathology)
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