Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism.

Abstract

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.

• Authors: Hyeong-Kyu Park, Rexford S Ahima
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 64 Issue 1 Pg. 24-34 (Jan 2015) ISSN: 1532-8600 [Electronic] United States
• PMID: 25199978 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Leptin

Topics

• Animals
• Energy Metabolism (physiology)
• Homeostasis (physiology)
• Humans
• Leptin (metabolism)
• Metabolic Diseases (metabolism, physiopathology)
• Neurosecretory Systems (metabolism, physiology)
• Obesity (metabolism, physiopathology)