Abstract | OBJECTIVES: To compare the short- and long-term outcomes of transradial approach (TRA) versus transfemoral approach (TFA) for primary percutaneous coronary intervention (PPCI) during a complete institutional transition from TFA to TRA. METHODS AND RESULTS: An all-comer population of ST-elevation myocardial infarction ( STEMI) patients (n=1808) who underwent PPCI using TRA (n=1162) and TFA (n=646) from October 2007 to December 2010 were enrolled. TRA was used in 25% of PPCIs by 2007 and in 96% of PPCIs in 2010. Primary endpoints were cardiovascular death and major adverse cardiac event ( MACE), defined as a composite of death, stroke, reinfarction, and target vessel revascularization at 30 days and 1 year. At 30 days, TRA compared to TFA was associated with a significant reduction of cardiovascular mortality (5.2% vs 10.5%; P<.001), significant MACE reduction (7.3% vs 12.5%; P<.001), fewer access-site complications (0.9% vs 8.2%; P<.001), and lower TIMI major bleeding (1.1% vs 4.3%; P<.001). At 1 year, the cardiovascular mortality and MACE rates were also in favor of the TRA group (6.9% vs 11.5%; P<.001 and 11.6% vs 20.1%; P<.001), respectively. CONCLUSION: Complete transition from femoral access to a preferred radial access is safe and effective for STEMI patients undergoing PPCI, with a favorable effect on short- and long-term outcomes.
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Authors | Sasko Kedev, Oliver Kalpak, Surya Dharma, Slobodan Antov, Jorgo Kostov, Hristo Pejkov, Igor Spiroski |
Journal | The Journal of invasive cardiology
(J Invasive Cardiol)
Vol. 26
Issue 9
Pg. 475-82
(Sep 2014)
ISSN: 1557-2501 [Electronic] United States |
PMID | 25198492
(Publication Type: Comparative Study, Journal Article, Observational Study)
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Chemical References |
- Anticoagulants
- Platelet Aggregation Inhibitors
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Cohort Studies
- Death, Sudden, Cardiac
(epidemiology)
- Electrocardiography
- Female
- Femoral Artery
- Hemostasis, Surgical
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
(physiopathology, therapy)
- Percutaneous Coronary Intervention
(methods)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Radial Artery
- Registries
- Retrospective Studies
- Stroke
(epidemiology)
- Treatment Outcome
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