Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats.

Abstract

The primary objective of the current study is to investigate the relationship between adipose tissue chromium and vanadium content and adipose tissue dysfunction in a model of diet-induced obesity. A total of 26 female Wistar rats were fed either standard or high-fat diet (31.6% of fat from total caloric content) for 3 months. High-fat-feeding resulted in 21 and 33% decrease in adipose tissue chromium and vanadium content, respectively. No change was seen in hair chromium or vanadium levels. Statistical analysis revealed a significant inverse correlation of adipose tissue Cr and V with animal morphometric parameters and adipocyte size. Significant inverse dependence was observed between adipose tissue Cr and V and serum leptin and proinflammatory cytokines' levels. At the same time, adipose tissue Cr and V levels were characterized by positive correlation between serum adiponectin and adiponectin/leptin ratio. Adipose tissue Cr and V were inversely correlated (p<0.05) with insulin and homeostatic model assessment insulin resistance index (HOMA-IR) levels. Cr and V concentrations were not correlated with serum glucose in either high-fat fed or control rats; however, both serum glucose and HOMA-IR levels were significantly higher in high-fat fed, compared to control, rats. The results allow to hypothesize that impairment of adipose tissue Cr and V content plays a certain role in the development of adipose tissue endocrine dysfunction in obesity.

• Authors: Alexey A Tinkov, Elizaveta V Popova, Valentina S Polyakova, Olga V Kwan, Anatoly V Skalny, Alexandr A Nikonorov
• Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (J Trace Elem Med Biol) Vol. 29 Pg. 176-81 (Jan 2015) ISSN: 1878-3252 [Electronic] Germany
• PMID: 25194956 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier GmbH. All rights reserved.

Chemical References

• Adipokines
• Blood Glucose
• Cytokines
• Inflammation Mediators
• Insulin
• Vanadium
• Chromium

Topics

• Adipocytes (cytology)
• Adipokines (blood)
• Adipose Tissue (metabolism)
• Animals
• Blood Glucose (metabolism)
• Cell Size
• Chromium (metabolism)
• Cytokines (blood)
• Diet, High-Fat
• Feeding Behavior
• Female
• Inflammation Mediators (metabolism)
• Insulin (blood)
• Rats, Wistar
• Vanadium (metabolism)