Abstract | PURPOSE: METHODS AND MATERIALS: This 3-arm randomized controlled study was conducted at a single center, tertiary cancer hospital between March 2011 and April 2013. Participants were randomized to 1 of 2 experimental groups ( aluminum-containing deodorant and soap or non- aluminum containing deodorant and soap) or a control group ( soap). A total of 333 participants were randomized. Generalized estimating equations were used to estimate and compare the odds of experiencing high levels of sweating and skin toxicity in each of the deodorant groups to the odds in the control group. The study evaluated a range of endpoints including objective measurements of axilla sweating, skin toxicity, pain, itch and burning. Quality of life was assessed with a validated questionnaire. RESULTS: Radiation characteristics were similar across all groups. Patients in the deodorant groups did not report significantly different ratings for axillary pain, itch, or burning compared with the control group. Patients in the aluminum-containing deodorant group experienced significantly less sweating than the control; the odds of their sweating being barely tolerable and frequently or always interfering with their daily activities was decreased by 85% (odds ratio, 0.15; 95% confidence interval, 0.03-0.91). CONCLUSIONS:
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Authors | Lucy Lewis, Sharron Carson, Sean Bydder, Mariyam Athifa, Anne M Williams, Alexandra Bremner |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 90
Issue 4
Pg. 765-71
(Nov 15 2014)
ISSN: 1879-355X [Electronic] United States |
PMID | 25194668
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Deodorants
- Soaps
- Aluminum
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aluminum
(administration & dosage, adverse effects)
- Axilla
(radiation effects)
- Breast Neoplasms
(radiotherapy)
- Deodorants
(adverse effects, chemistry)
- Double-Blind Method
- Female
- Humans
- Middle Aged
- Odds Ratio
- Radiodermatitis
(chemically induced)
- Soaps
(adverse effects, chemistry)
- Sweating
(drug effects)
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