Abstract | BACKGROUND AND PURPOSE: METHODS: The study population consisted of 90 137 postmenopausal women aged 50 to 79 at enrollment, free of stroke history at baseline, followed up prospectively for an average of 11 years. Outcome variables were total, ischemic, and hemorrhagic stroke, and all-cause mortality. Incidence was compared across quartiles of dietary potassium intake, and hazard ratios were obtained from Cox proportional hazards models after adjusting for potential confounding variables, and in women with hypertension and nonhypertension separately. RESULTS: Mean dietary potassium intake was 2611 mg/d. Highest quartile of potassium intake was associated with lower incidence of ischemic and hemorrhagic stroke and total mortality. Multivariate analyses comparing highest to lowest quartile of potassium intake indicated a hazard ratio of 0.90 (95% confidence interval, 0.85-0.95) for all-cause mortality, 0.88 (95% confidence interval, 0.79-0.98) for all stroke, and 0.84 (95% confidence interval, 0.74-0.96) for ischemic stroke. The effect on ischemic stroke was more apparent in women with nonhypertension among whom there was a 27% lower risk with hazard ratio of 0.73 (95% confidence interval, 0.60-0.88), interaction P<0.10. There was no association with hemorrhagic stroke. CONCLUSIONS: High potassium intake is associated with a lower risk of all stroke and ischemic stroke, as well as all-cause mortality in older women, particularly those who are not hypertensive.
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Authors | Arjun Seth, Yasmin Mossavar-Rahmani, Victor Kamensky, Brian Silver, Kamakshi Lakshminarayan, Ross Prentice, Linda Van Horn, Sylvia Wassertheil-Smoller |
Journal | Stroke
(Stroke)
Vol. 45
Issue 10
Pg. 2874-80
(Oct 2014)
ISSN: 1524-4628 [Electronic] United States |
PMID | 25190445
(Publication Type: Journal Article, Observational Study, Research Support, N.I.H., Extramural)
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Copyright | © 2014 American Heart Association, Inc. |
Chemical References |
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Topics |
- Aged
- Female
- Humans
- Hypertension
(complications)
- Incidence
- Middle Aged
- Postmenopause
- Potassium, Dietary
- Proportional Hazards Models
- Risk Factors
- Stroke
(complications, epidemiology)
- Women's Health
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