HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

FANCD2 is a target for caspase 3 during DNA damage-induced apoptosis.

Abstract
The Fanconi anemia (FA) pathway, of which the FANCD2 protein is a key component, plays crucial roles in the maintenance of hematopoietic stem cells and suppression of carcinogenesis. However, the function of FANCD2 remains unclear. Here, we report that FANCD2 is a novel and specific substrate of caspase 3. Cleavage of FANCD2 by caspase 3 did not require either the FA core complex or mono-ubiquitylation of FANCD2, and was stimulated by p53. In addition, we identified the cleavage sites and generated cell lines that stably express a caspase-resistant FANCD2 mutant. Our data suggest that FANCD2 is regulated by caspase-mediated degradation during apoptosis induced by DNA damage.
AuthorsWataru Sakai, Kaoru Sugasawa
JournalFEBS letters (FEBS Lett) Vol. 588 Issue 20 Pg. 3778-85 (Oct 16 2014) ISSN: 1873-3468 [Electronic] England
PMID25176410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References
  • BRCA2 Protein
  • BRCA2 protein, human
  • Tumor Suppressor Protein p53
  • Caspase 3
Topics
  • Apoptosis
  • BRCA2 Protein (genetics, metabolism)
  • Caspase 3 (metabolism)
  • DNA Damage
  • HCT116 Cells
  • HeLa Cells
  • Humans
  • Tumor Suppressor Protein p53 (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: