A concise diastereoselective approach to enantioenriched substituted piperidines and their in vitro cytotoxicity evaluation.

Abstract	A library of diversely stereo-oriented, highly substituted 2,6-cis piperidine derivatives were synthesized, and evaluated for their anticancer activity in cancer cells that included A549 (lung cancer, CCL-185), MCF7 (breast cancer (HTB-22), DU145 (prostate cancer (HTB-81), and HeLa (cervical cancer, CCL-2). One stereo-variant emerged as a promising candidate for further design based structure-activity studies.
Authors	Gullapalli Kumaraswamy, Rangaraju Satish Kumar, Bitla Sampath, Y Poornachandra, C Ganesh Kumar, Sahithya Phani Babu Vemulapalli, Jagadeesh Bharatam
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 24 Issue 18 Pg. 4439-4443 (Sep 15 2014) ISSN: 1464-3405 [Electronic] England
PMID	25172418 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References	Antineoplastic Agents Piperidines
Topics	Antineoplastic Agents (chemical synthesis, chemistry, pharmacology) Cell Line, Tumor Cell Proliferation (drug effects) Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells Humans MCF-7 Cells Molecular Structure Piperidines (chemical synthesis, chemistry, pharmacology) Stereoisomerism Structure-Activity Relationship

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