Gastrointestinal symptoms: a comparison between patients undergoing peritoneal dialysis and hemodialysis.

Abstract

AIM:

To compare the prevalence and diversity of gastrointestinal (GI) symptoms in patients undergoing peritoneal dialysis (PD) and hemodialysis (HD).

METHODS:

Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores were calculated from a modified gastrointestinal symptom rating scale (GSRS) 18-item questionnaire, including items concerning eating dysfunction, and were used for measuring GI symptoms. Information on patient age, condition contributing to end-stage renal disease and the most recent dialysis adequacy assessment (serum Kt/V urea value) was obtained from the follow-up database and by interviewing patients and/or reviewing the medical records. Differences between the HD and PD groups were evaluated using Student's t, Pearson's χ(2) or Fisher's exact tests.

RESULTS:

The overall prevalence of GI symptoms, defined by a GSRS > 1, in end-stage renal disease patients was 70.7% (208/294), which differed between HD and PD patients (76.4% vs 61.6%, P < 0.01). HD patients had a higher prevalence of constipation, abdominal pain and diarrhea compared to PD patients (36.3% vs 17.9%, 32.4% vs 5.4%, 17.6% vs 4.5%, respectively, P < 0.05). PD patients had a higher prevalence of reflux compared to HD patients (32.1% vs 24.2%, P < 0.05). Additionally, reflux and eating dysfunction were more severe in PD patients (GSRS: 1.71 ± 1.15 vs 1.30 ± 0.67, 1.57 ± 0.84 vs 1.39 ± 0.61, respectively, P < 0.05), whereas HD patients had greater abdominal pain, diarrhea and constipation (GSRS: 1.22 ± 0.39 vs 1.04 ± 0.19, 1.19 ± 0.53 vs 1.07 ± 0.35, 1.51 ± 0.83 vs 1.23 ± 0.58, respectively, P < 0.05). Finally, 14.8% (27/182) of HD patients presented with more than three GI symptoms, compared to 7.2% (8/112) of PD patients (P < 0.01).

CONCLUSION:

HD and PD patients differ in prevalence, severity and diversity of GI symptoms.

• Authors: Rui Dong, Zhi-Yong Guo, Jia-Rong Ding, Yang-Yang Zhou, Hao Wu
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 20 Issue 32 Pg. 11370-5 (Aug 28 2014) ISSN: 2219-2840 [Electronic] United States
• PMID: 25170224 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Chi-Square Distribution
• China (epidemiology)
• Female
• Gastrointestinal Diseases (diagnosis, epidemiology)
• Humans
• Kidney Failure, Chronic (diagnosis, epidemiology, therapy)
• Male
• Middle Aged
• Peritoneal Dialysis (adverse effects)
• Prevalence
• Renal Dialysis (adverse effects)
• Retrospective Studies
• Risk Factors
• Severity of Illness Index
• Surveys and Questionnaires
• Treatment Outcome