Abstract | OBJECTIVE: CASE SERIES: We present 3 cases of severe serotonin syndrome in adolescents requiring intubation that were refractory to midazolam and/or propofol. Dexmedetomidine, an α-2 receptor agonist, was used in all 3 cases with temporal stabilization of the autonomic nervous system and improvement of agitation, and aided in successful extubation. DISCUSSION: Although no human studies exist, rat and mouse models offer evidence that dexmedetomidine can reduce serotonin excess and stabilize signs of serotonin neurotoxicity. CONCLUSION:
|
Authors | William F Rushton, Nathan P Charlton |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 48
Issue 12
Pg. 1651-4
(Dec 2014)
ISSN: 1542-6270 [Electronic] United States |
PMID | 25169248
(Publication Type: Case Reports, Journal Article)
|
Copyright | © The Author(s) 2014. |
Chemical References |
- Adrenergic alpha-Agonists
- Hypnotics and Sedatives
- Benzodiazepines
- Dexmedetomidine
- Midazolam
- Propofol
|
Topics |
- Adolescent
- Adrenergic alpha-Agonists
(therapeutic use)
- Benzodiazepines
(therapeutic use)
- Dexmedetomidine
(therapeutic use)
- Female
- Humans
- Hypnotics and Sedatives
(therapeutic use)
- Male
- Midazolam
(therapeutic use)
- Propofol
(therapeutic use)
- Psychomotor Agitation
(complications, drug therapy)
- Serotonin Syndrome
(complications, drug therapy)
- Treatment Failure
|