Elastography in the differential diagnosis of thyroid nodules.

Abstract

Despite the publication of a recent meta-analysis of elastography in thyroid nodules, further work is necessary on this issue in different populations. In this study, we aimed to evaluate the clinical value of elastography on nodular goiters in mild iodine-deficient regions without excluding patients according to nodule characteristics. This prospective study was conducted between April 2010 and December 2011 in Yıldırım Beyazıt Dıskapı Research Hospital Endocrinology outpatient clinic. Five hundred twenty-eight nodular goiter patients who underwent thyroid fine-needle aspiration biopsy were included in our study. Elastography scores and indexes were measured with real-time ultrasound elastography (Hitachi® EUB 7000 HV machine with 13 MHz linear transducer). There were 471 females and 57 males and their ages ranged from 45 years to 78 years. A total of 601 nodules were evaluated in these patients. The area under the curve (AUC) for the elasto score was 0.91 (p < 0.0001) and AUC for the strain index (SI) was 0.96 (p < 0.0001). We suggest that the SI reflects malignancy better than the elasto score. We conclude that elastography scores greater than 3 have 76% sensitivity and 96% specificity for diagnosing malignancy. For SI, we conclude that 3.75 (83% sensitivity and 95% specificity) is the cutoff point. Elasto score and SI measurements of thyroid nodules in our population are efficient and increase the diagnostic performance of the sonography.

• Authors: Erman Çakal, Mustafa Şahin, İlknur Öztürk Ünsal, Aşkın Güngüneş, Esra Akkaymak, Evrim Çakır Özkaya, Nujen Çolak Bozkurt, Mustafa Özbek, Tuncay Delibaşı
• Journal: Ultrasonic imaging (Ultrason Imaging) Vol. 37 Issue 3 Pg. 251-7 (Jul 2015) ISSN: 1096-0910 [Electronic] England
• PMID: 25161183 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2014.

Topics

• Aged
• Area Under Curve
• Diagnosis, Differential
• Elasticity Imaging Techniques
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Reproducibility of Results
• Sensitivity and Specificity
• Thyroid Nodule (diagnostic imaging)