Efficacy and tolerability of luliconazole cream 1% for dermatophytoses: a meta-analysis.

Abstract

We evaluated the efficacy and safety of luliconazole cream 1% in the treatment of dermatophytoses. According to our meta-analysis, short-term treatment of luliconazole cream 1% can result in the complete clearance of dermatophytoses. It showed that 1% luliconazole was more effective than controlled drugs or vehicle (week 4: odds ratio = 1.46, 95% confidence interval = 1.12-1.91), and no more adverse events occurred in the 1% luliconazole group (week 4: odds ratio = 1.01, 95% confidence interval = 0.71-1.44). This effect strengthens the evidence for luliconazole cream 1% being more effective than vehicle, 1% terbinafine, 1% bifonazole, and 0.1% or 0.5% luliconazole.

• Authors: Xiaowei Feng, Jinwei Xie, Kaiwen Zhuang, Yuping Ran
• Journal: The Journal of dermatology (J Dermatol) Vol. 41 Issue 9 Pg. 779-82 (Sep 2014) ISSN: 1346-8138 [Electronic] England
• PMID: 25156082 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2014 Japanese Dermatological Association.

Chemical References

• Imidazoles
• luliconazole

Topics

• Humans
• Imidazoles (administration & dosage, adverse effects)
• Randomized Controlled Trials as Topic
• Skin Cream
• Tinea (drug therapy)