Abstract |
Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Serum levels of both MMP-9 and TIMP-1 were significantly higher in infants with HHV-6 infection than in controls. Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. In infants with HHV-6 infection, positive correlations were found between serum MMP-9 concentrations and the white blood cells (WBC) count, and between serum TIMP-1 concentrations and the WBC count. Positive correlations were also found between the amounts of HHV-6 DNA and the ratios of MMP-9/TIMP-1 in infants with HHV-6 infection. In conclusion, we suggest that high serum levels of MMP-9 and TIMP-1 in infants with HHV-6 infection may induce dysfunction of the blood-brain barrier, eventually causing febrile seizures.
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Authors | Setsuaki Kittaka, Shunji Hasegawa, Yoshinori Ito, Noriko Ohbuchi, Eitaro Suzuki, Shoji Kawano, Yoshiharu Aoki, Kenji Nakatsuka, Keiko Kudo, Hiroyuki Wakiguchi, Madoka Kajimoto, Takeshi Matsushige, Takashi Ichiyama |
Journal | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
(J Infect Chemother)
Vol. 20
Issue 11
Pg. 716-21
(Nov 2014)
ISSN: 1437-7780 [Electronic] Netherlands |
PMID | 25156011
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- DNA, Viral
- TIMP1 protein, human
- Tissue Inhibitor of Metalloproteinase-1
- Matrix Metalloproteinase 9
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Topics |
- Blood-Brain Barrier
- Child, Preschool
- DNA, Viral
(blood)
- Exanthema Subitum
(blood, complications)
- Female
- Herpesvirus 6, Human
- Humans
- Infant
- Leukocyte Count
- Male
- Matrix Metalloproteinase 9
(blood)
- Seizures, Febrile
(blood, complications)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
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