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Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures.

Abstract
Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Serum levels of both MMP-9 and TIMP-1 were significantly higher in infants with HHV-6 infection than in controls. Serum TIMP-1 levels were significantly higher in infants with febrile seizures than in infants without febrile seizures. Serum MMP-9/TIMP-1 ratios were significantly lower in infants with febrile seizures than in infants without febrile seizures. In infants with HHV-6 infection, positive correlations were found between serum MMP-9 concentrations and the white blood cells (WBC) count, and between serum TIMP-1 concentrations and the WBC count. Positive correlations were also found between the amounts of HHV-6 DNA and the ratios of MMP-9/TIMP-1 in infants with HHV-6 infection. In conclusion, we suggest that high serum levels of MMP-9 and TIMP-1 in infants with HHV-6 infection may induce dysfunction of the blood-brain barrier, eventually causing febrile seizures.
AuthorsSetsuaki Kittaka, Shunji Hasegawa, Yoshinori Ito, Noriko Ohbuchi, Eitaro Suzuki, Shoji Kawano, Yoshiharu Aoki, Kenji Nakatsuka, Keiko Kudo, Hiroyuki Wakiguchi, Madoka Kajimoto, Takeshi Matsushige, Takashi Ichiyama
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 20 Issue 11 Pg. 716-21 (Nov 2014) ISSN: 1437-7780 [Electronic] Netherlands
PMID25156011 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • DNA, Viral
  • TIMP1 protein, human
  • Tissue Inhibitor of Metalloproteinase-1
  • Matrix Metalloproteinase 9
Topics
  • Blood-Brain Barrier
  • Child, Preschool
  • DNA, Viral (blood)
  • Exanthema Subitum (blood, complications)
  • Female
  • Herpesvirus 6, Human
  • Humans
  • Infant
  • Leukocyte Count
  • Male
  • Matrix Metalloproteinase 9 (blood)
  • Seizures, Febrile (blood, complications)
  • Tissue Inhibitor of Metalloproteinase-1 (blood)

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