HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protective effects of epigallocatechin gallate (EGCG) on streptozotocin-induced diabetic nephropathy in mice.

Abstract
There is increasing evidence suggesting that antioxidants in green tea extracts may protect kidneys on the progression of end-stage renal disease. We investigated the protective impacts of (-)-epigallocatechin 3-O-gallate (EGCG) against streptozotocin (STZ)-induced diabetic nephropathy in mice. The mice were divided into 5 groups (n=10 per group): control (saline, i.p.), STZ (200mg/kg, i.p.), EGCG50 (50mg/kg, S.Q.), EGCG100 (100mg/kg, S.Q.), and EGCG200 (200mg/kg, S.Q.). Animals were sacrificed at scheduled times after EGCG administration and then quantitative and qualitative analysis were performed. Compared with the control group, the STZ group showed an increase in levels of blood glucose, blood urea nitrogen, creatinine and urine protein amounts with a decrease in body weight. All the above parameters were significantly reversed with EGCG treatment, especially in the EGCG100 group. After STZ injection, there was a mesangial proliferation with increased renal osteopontin accumulation and its protein expression in the glomeruli and the proximal tubules. Mice kidneys after EGCG-treatment showed a reduced expression of above parameters and relatively improved histopathological findings. These results indicated that EGCG 100mg/kg might provide an effective protection against STZ-induced diabetic nephropathy in mice by osteopontin suppression.
AuthorsSang Pil Yoon, Young Hee Maeng, Ran Hong, Byung Rai Lee, Chong Gue Kim, Hyun Lee Kim, Jong Hoon Chung, Byung Chul Shin
JournalActa histochemica (Acta Histochem) Vol. 116 Issue 8 Pg. 1210-5 (Oct 2014) ISSN: 1618-0372 [Electronic] Germany
PMID25154791 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier GmbH. All rights reserved.
Chemical References
  • Streptozocin
  • Catechin
  • epigallocatechin gallate
Topics
  • Animals
  • Blotting, Western
  • Body Weight (drug effects)
  • Catechin (analogs & derivatives, pharmacology)
  • Diabetic Nephropathies (chemically induced, drug therapy, metabolism)
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Inbred ICR
  • Random Allocation
  • Streptozocin (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: