Abstract | INTRODUCTION: Malignant transformation of sex- steroid dependent tissues is associated with the loss of expression of sex steroid receptors as well as of the tumor suppression gene p53. The aim of this study is to evaluate the expression of sex- steroid receptors, p53 and Ki-67 in specimens from pre-malignant and malignant cervical epithelial lesions throughout the menstrual cycle. MATERIAL AND METHODS: RESULTS: CONCLUSION: The findings of this study suggest that tumor cervical cells evade normal growth control by sex steroid hormones while synchronously abnormal regulatory mechanisms acquire control of the cell cycle.
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Authors | Marinos Nikolaou, Dimitra Koumoundourou, Panagiota Ravazoula, Margarita Papadopoulou, Georgios Michail, Georgios Decavalas |
Journal | Medicinski pregled
(Med Pregl)
2014 Jul-Aug
Vol. 67
Issue 7-8
Pg. 202-7
ISSN: 0025-8105 [Print] Serbia |
PMID | 25151759
(Publication Type: Journal Article)
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Chemical References |
- Ki-67 Antigen
- Receptors, Estrogen
- Receptors, Progesterone
- Tumor Suppressor Protein p53
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Topics |
- Carcinoma, Squamous Cell
(chemistry)
- Cell Transformation, Neoplastic
- Cervix Uteri
(chemistry)
- Epithelium
(chemistry)
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(analysis)
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Tumor Suppressor Protein p53
(analysis, genetics)
- Uterine Cervical Neoplasms
(chemistry)
- Uterine Cervical Dysplasia
(chemistry)
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