Abstract |
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
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Authors | Cecilia Zavala-Tecuapetla, Hana Kubová, Jakub Otáhal, Grygoriy Tsenov, Pavel Mareš |
Journal | Pharmacological reports : PR
(Pharmacol Rep)
Vol. 66
Issue 5
Pg. 927-30
(Oct 2014)
ISSN: 2299-5684 [Electronic] Switzerland |
PMID | 25150003
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. |
Chemical References |
- 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine
- Anticonvulsants
- Pyridines
- Receptor, Metabotropic Glutamate 5
- Thiazoles
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Topics |
- Age Factors
- Animals
- Anticonvulsants
(administration & dosage, pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Epilepsy, Complex Partial
(drug therapy)
- Hippocampus
(drug effects, metabolism)
- Pyridines
(administration & dosage, pharmacology)
- Rats
- Rats, Wistar
- Receptor, Metabotropic Glutamate 5
(antagonists & inhibitors)
- Thiazoles
(administration & dosage, pharmacology)
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