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Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.

Abstract
Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
AuthorsCecilia Zavala-Tecuapetla, Hana Kubová, Jakub Otáhal, Grygoriy Tsenov, Pavel Mareš
JournalPharmacological reports : PR (Pharmacol Rep) Vol. 66 Issue 5 Pg. 927-30 (Oct 2014) ISSN: 2299-5684 [Electronic] Switzerland
PMID25150003 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Chemical References
  • 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine
  • Anticonvulsants
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Thiazoles
Topics
  • Age Factors
  • Animals
  • Anticonvulsants (administration & dosage, pharmacology)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Epilepsy, Complex Partial (drug therapy)
  • Hippocampus (drug effects, metabolism)
  • Pyridines (administration & dosage, pharmacology)
  • Rats
  • Rats, Wistar
  • Receptor, Metabotropic Glutamate 5 (antagonists & inhibitors)
  • Thiazoles (administration & dosage, pharmacology)

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