[Effectiveness of cicletanine on lesions in spontaneously hypertensive rats. Curative study--dose-effect relationship].

Abstract

Genetically hypertensive rats receiving a high sodium content diet develop, within weeks of their birth, major alterations of tissues and blood vessels. The purpose of this study was to evaluate the effects of cicletanine, a synthetic antihypertensive drug, on the progress of genetic hypertension. Iffa Credo SHR-SP male rats aged 11 weeks were divided into 4 groups. One group was used as control and 3 groups were treated with oral cicletanine in doses of 10, 30 and 90 mg/kg/day respectively. The control group showed a high mortality rate due to a significant decrease of weight gain and a highly significant increase of blood pressure, these changes being associated with lesions of tissues and vessels in the brain, heart and kidneys. A curative treatment with cicletanine improved these parameters and was accompanied by good tissue preservation. The curative effect of cicletanine seems to be due to an increase in endogenous prostaglandin synthesis.

• Authors: M T Droy-Lefaix, M M Ruchoux, P Berthet, F Bakri, D Bosquet, G Narcisse, G Guillemain
• Journal: Archives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 82 Spec No 4 Pg. 163-8 (Nov 1989) ISSN: 0003-9683 [Print] France
• Vernacular Title: Efficacité du ciclétanine sur les lésions du rat spontanément hypertendu. Etude curative--relation dose-effet.
• PMID: 2514659 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diuretics
• Pyridines
• cicletanine

Topics

• Animals
• Brain Diseases (etiology, pathology)
• Cardiomyopathies (etiology, pathology)
• Diuretics (therapeutic use)
• Dose-Response Relationship, Drug
• Hypertension (complications, drug therapy, pathology)
• Kidney Diseases (etiology, pathology)
• Male
• Organ Size (drug effects)
• Pyridines
• Rats
• Rats, Inbred SHR