γδT cells regulate chronic airway inflammation and development of airway remodelling.

Abstract

BACKGROUND:

γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of acute inflammation. However, their contribution to inflammation-associated airway remodelling remains unexplored. Here we investigate the effects of γδT cell blockade on established allergic airway inflammation and development of remodelling.

METHODS:

Sensitised mice were exposed to prolonged ovalbumin challenge or continuous house-dust mite exposure to induce chronic inflammation and remodelling. Functional blocking anti-TCRδ antibody was administered therapeutically, and parameters of airway inflammation and remodelling were examined.

RESULTS:

Therapeutic blockade of γδT cells prevented the typical resolution of acute airway inflammation characterised by elevated eosinophil and Th2 cell numbers. Moreover, the lung displayed exacerbated airway remodelling, typified by excess peribronchiolar collagen deposition.

CONCLUSIONS:

These results demonstrate a unique role for γδT cells in constraining allergen-induced airway remodelling. Manipulating the γδT cell compartment may therefore contribute to strategies to prevent and treat remodelling.

• Authors: J R Murdoch, L G Gregory, C M Lloyd
• Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (Clin Exp Allergy) Vol. 44 Issue 11 Pg. 1386-98 (Nov 2014) ISSN: 1365-2222 [Electronic] England
• PMID: 25146585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons Ltd.

Chemical References

• Proliferating Cell Nuclear Antigen
• Receptors, Antigen, T-Cell, gamma-delta
• Ovalbumin

Topics

• Airway Remodeling
• Animals
• Chronic Disease
• Disease Models, Animal
• Eosinophils (immunology)
• Female
• Inflammation (immunology, metabolism, pathology)
• Mice
• Ovalbumin (adverse effects, immunology)
• Proliferating Cell Nuclear Antigen (immunology)
• Receptors, Antigen, T-Cell, gamma-delta (metabolism)
• Respiratory Tract Diseases (immunology, metabolism, pathology)
• T-Lymphocyte Subsets (immunology, metabolism)
• Th2 Cells (immunology)