Abstract | OBJECTIVES: METHODS: MEDLINE, EMBASE, CINAHL and the Cochrane Library (through February 5, 2014) were searched for relevant studies. Two independent reviewers reviewed and extracted relevant data. Risk estimates were aggregated comparing the lowest (reference) quintile with highest quintile of intake using inverse variance random effect models and expressed as risk ratios (RR) with 95% confidence intervals (CIs). Interstudy heterogeneity was assessed (Cochran Q statistic) and quantified (I(2) statistic). The Newcastle-Ottawa Scale assessed study quality. Clinicaltrials.gov NCT01608620. RESULTS: Eligibility criteria were met by 3 prospective cohorts (n = 37,375 men and 185,855 women) with 58,162 cases of hypertension observed over 2,502,357 person-years of follow-up. Median fructose intake was 5.7-6.0% total energy in the lowest quintile and 13.9-14.3% total energy in the highest quintile. Fructose intake was not associated with incident hypertension (RR = 1.02, 95% CI, 0.99-1.04), with no evidence of heterogeneity (I(2) = 0%, p = 0.59). Spline curve modeling showed a U-shaped relationship with a negative association at intakes ≤50th percentile (∼10% total energy) and a positive association at higher intakes. CONCLUSIONS: Total fructose intake was not associated with an increased risk of hypertension in 3 large prospective cohorts of U.S. men and women.
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Authors | Viranda H Jayalath, John L Sievenpiper, Russell J de Souza, Vanessa Ha, Arash Mirrahimi, Ingrid D Santaren, Sonia Blanco Mejia, Marco Di Buono, Alexandra L Jenkins, Lawrence A Leiter, Thomas M S Wolever, Joseph Beyene, Cyril W C Kendall, David J A Jenkins |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 33
Issue 4
Pg. 328-39
( 2014)
ISSN: 1541-1087 [Electronic] United States |
PMID | 25144126
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
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Topics |
- Blood Pressure
- Databases, Factual
- Fructose
(administration & dosage, adverse effects)
- Humans
- Hypertension
(blood, epidemiology)
- Observational Studies as Topic
- Randomized Controlled Trials as Topic
- Risk Factors
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