EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.

Abstract

Extracellular metalloproteinase inducer (EMMPRIN) and a disintegrin and metalloproteinase (ADAM12) play a major role in cancer invasion and metastasis owing to the fact that they are directly related to the cell microenvironment and extracellular matrix (ECM) degradation. The aim of this study was to search for an answer to the question "whether the determination of EMMPRIN and ADAM12 values especially in urine may be helpful for the early diagnosis of prostate cancer without employing invasive methods" and also to check whether they may be useful for the determination of the patients with high metastasis risk. Peripheral blood and urine from 66 prostate cancer patients (40 local, 20 locally advanced, 6 metastatic) and 14 healthy controls were evaluated by enzyme-linked immunosorbent assay (ELISA) method. Serum EMMPRIN and ADAM12 values of the patients were seen to be statistically higher than the serum EMMPRIN and ADAM12 values of the healthy controls (p=0.01 and p=0.001, respectively). The urine ADAM12 levels were significantly higher in patients (p=0.013). No significant relationships were found between urine EMMPRIN values of the patients and the healthy controls (p>0.05). Positive correlation between urine EMMPRIN-urine ADAM12 tests was found in total patients group (r=0.683, p=0.001). Our preliminary results revealed that serum EMMPRIN and ADAM12 values and urine ADAM12 values may be useful markers in prostate cancer therapy. Due to the high correlation between these two tests, we are of the opinion that the use of urine ADAM12 in clinic may be sufficient and favorable together with prostate-specific antigen (PSA) for treatment.

• Authors: Elif Bilgin Doğru, Yavuz Dizdar, Ece Akşit, Feyyaz Ural, Öner Şanlı, Vildan Yasasever
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 11 Pg. 11647-53 (Nov 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25139103 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BSG protein, human
• Biomarkers, Tumor
• Membrane Proteins
• Basigin
• ADAM Proteins
• ADAM12 Protein
• ADAM12 protein, human

Topics

• ADAM Proteins (metabolism)
• ADAM12 Protein
• Adenocarcinoma (blood, secondary, urine)
• Adult
• Aged
• Basigin (metabolism)
• Biomarkers, Tumor (metabolism)
• Case-Control Studies
• Disease Progression
• Enzyme-Linked Immunosorbent Assay
• Follow-Up Studies
• Humans
• Lymphatic Metastasis
• Male
• Membrane Proteins (metabolism)
• Middle Aged
• Neoplasm Staging
• Prognosis
• Prospective Studies
• Prostatic Neoplasms (blood, pathology, urine)