Additional correction of OAB symptoms by two anti-muscarinics for men over 50 years old with residual symptoms of moderate prostatic obstruction after treatment with Tamsulosin.

Abstract

OBJECTIVES:

To study the effectiveness and safety of combined standard-dosed Solifenacin and Trospium for management of symptoms of overactive bladder (OAB) in elderly patients after the treatment with Tamsulosin.

PATIENTS AND METHODS:

A total of 417 men over 50 years of age (average age 57.9 (8.3)) with diagnosed prostatic obstruction (score 8-19 according to I-PSS), who had not taken Tamsulosin before, were enrolled in the study. I-PSS questionnaire (from 8 to 19 - moderate) and Awareness Tool questionnaire for evaluating OAB symptoms (total score for OAB symptoms over 8) were used at the beginning and at the end of the observation. Also, urodynamic parameters were examined.

RESULT:

Percentage of patients with prevalent symptoms of obstruction of urethra decreases after the treatment with Tamsulosin and then rises again (36.2%), but absolute number of patients remains smaller than initial data. Percentage of patients with relative prevalence of symptoms of overactive bladder slightly increases against administration of Tamsulosin and reaches initial values at the time of administration of anti-muscarinic drugs with absolute decrease in number of such patients.

CONCLUSION:

Combination of Trospium and Solifenacin is an effective way to manage residual symptoms of hyperactive bladder during treatment of early obstruction of urinary bladder.

• Authors: Kirill Kosilov, Sergey Loparev, Marina Ivanovskaya, Liliya Kosilova
• Journal: The aging male : the official journal of the International Society for the Study of the Aging Male (Aging Male) Vol. 18 Issue 1 Pg. 44-8 (Mar 2015) ISSN: 1473-0790 [Electronic] England
• PMID: 25136746 (Publication Type: Journal Article)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Benzilates
• Muscarinic Antagonists
• Nortropanes
• Sulfonamides
• trospium chloride
• Tamsulosin
• Solifenacin Succinate

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Aged
• Benzilates (therapeutic use)
• Drug Therapy, Combination
• Humans
• Male
• Middle Aged
• Muscarinic Antagonists (therapeutic use)
• Nortropanes (therapeutic use)
• Prostatic Hyperplasia (drug therapy)
• Solifenacin Succinate (therapeutic use)
• Sulfonamides (therapeutic use)
• Tamsulosin
• Urinary Bladder Neck Obstruction (drug therapy)
• Urinary Bladder, Overactive (drug therapy)