Abstract | BACKGROUND: METHODS: RESULTS: (1) Pre-treatment with AJN attenuates wet dog shakes and episodes of writhing to approximately 50% or less of those observed in the morphine group (p < 0.01). (2) AJN post-treatment dose-dependently reduced the number of wet dog shakes (p < 0.01), and the episodes of writhing (p < 0.01). (3) Pre-treatment with AJN effectively interdicted the morphine-induced decreases in the levels of DAT, D2R, and TH in the striatum (p < 0.01) such that they remained at nearly normal levels. (4) Post-treatment with AJN restored DAT and D2R to the normal levels (p < 0.01) and the level of TH to 87% of normal in the striatum. CONCLUSIONS: AJN can effectively alleviate opioid withdrawal symptoms and preserve or restore the DAT, D2R, and TH levels in the striatum. The mechanism underlying the effect of AJN on withdrawal symptoms may be related to the modulation of the dopamine system by AJN. These results suggest that AJN may help to prevent relapse in opioid dependence treatment.
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Authors | Jin-Long Gao, Shao-Ang Tu, Jia Liu, Jin-Ming Zhang, Yiyun Huang, Mei Han, Jian-Hui Liang |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 14
Pg. 308
(Aug 19 2014)
ISSN: 1472-6882 [Electronic] England |
PMID | 25134609
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Morphine
- Dopamine
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Topics |
- Animals
- Brain
(drug effects)
- Dopamine
(metabolism)
- Drugs, Chinese Herbal
(administration & dosage)
- Humans
- Male
- Morphine
(adverse effects)
- Morphine Dependence
(drug therapy, metabolism)
- Rats
- Rats, Wistar
- Substance Withdrawal Syndrome
(drug therapy, metabolism)
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