Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells.

Abstract

Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C virus replication and also in the cells implicated in the inflammatory response to the viral infection.

• Authors: Pau Ruiz-Sanchis, Benjamin M Wohl, Anton A A Smith, Kaja Zuwala, Jesper Melchjorsen, Martin Tolstrup, Alexander N Zelikin
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 4 Issue 1 Pg. 65-8 (Jan 07 2015) ISSN: 2192-2659 [Electronic] Germany
• PMID: 25132665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antiviral Agents
• Polymethacrylic Acids
• Prodrugs
• polymethacrylic acid
• Ribavirin

Topics

• Antiviral Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line
• Gene Expression Regulation, Viral (drug effects)
• Genome, Viral
• Hepacivirus (genetics, metabolism)
• Hepatitis C (drug therapy, genetics, metabolism, pathology)
• Humans
• Polymethacrylic Acids (chemical synthesis, chemistry, pharmacology)
• Prodrugs (chemical synthesis, chemistry, pharmacology)
• Ribavirin (analogs & derivatives, chemical synthesis, chemistry, pharmacology)