[A case of gastric adenosquamous carcinoma with peritoneal dissemination in which treatment with S-1 plus paclitaxel therapy resulted in improved long-term survival].

Abstract

Gastric adenosquamous carcinoma is a rare malignancy with a poor prognosis. We recently performed palliative gastrectomy for a gastric adenosquamous carcinoma with peritoneal dissemination and provided a course of systemic chemotherapy with S-1 plus paclitaxel(PTX)after the surgery. No serious adverse events were observed, and treatment with S-1 plus PTX was continued for 1 year before being switched to adjuvant chemotherapy with S-1 alone for another year. The tumor maker levels normalized within 2 months of the initial treatment, and the peritoneal dissemination could no longer be detected by abdominal computed tomography(CT). The patient remained in clinical remission and maintained long-term survival of over 8 years.

• Authors: Masamitsu Hirano, Yuki Ozamoto, Masumi Ichinose, Takeshi Togawa, Nobuyuki Takao, Akiyoshi Mizumoto, Manami Tatsuno, Yoshihiro Yamamoto, Yutaka Yonemura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 7 Pg. 885-8 (Jul 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25131877 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Paclitaxel

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Carcinoma, Adenosquamous (drug therapy, surgery)
• Chemotherapy, Adjuvant
• Drug Combinations
• Gastrectomy
• Humans
• Male
• Oxonic Acid (administration & dosage)
• Paclitaxel (administration & dosage)
• Peritoneal Neoplasms (drug therapy, secondary)
• Stomach Neoplasms (drug therapy, pathology, surgery)
• Tegafur (administration & dosage)
• Time Factors