Abstract | PURPOSE: METHODS: Subjects were dental trainee residents and faculty members of Okayama University Hospital who were aware of having severe or no SB. SB frequency was assessed for 3-consecutive nights by a self-contained electromyographic detector/analyzer, which indicated individual SB levels as one of four grades (score 0, 1, 2 and 3). Subjects were classified as normal control (NC) when SB scores indicated only 0 or 1 during the 3 nights, or as severe SB for scores 2 or 3. Those subjects whose scores fluctuated from 0 to 3 during the 3 nights were omitted from further analysis. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. Amounts of SERTs proteins collected from peripheral platelets were quantified using ELISA, and SERTs transport activity was assessed by uptake assay using [3H]-5-HT. RESULTS: Thirteen severe SB subjects and 7 NC subjects were eligible. Gender distribution, mean age, 5-HT concentration and total amounts of SERT protein in platelets showed no significant differences between NC and severe SB (p=0.85: Chi-squared test; p=0.64, 0.26, 0.46: t-test). However, [3H]-5-HT uptake by platelets was significantly greater in NC compared to severe SB subjects (12.79±1.97, 8.27±1.91 fmol/10(5) platelets/min, p<0.001, t-test). CONCLUSION:
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Authors | Hajime Minakuchi, Chiharu Sogawa, Emilio Satoshi Hara, Haruna Miki, Kenji Maekawa, Norio Sogawa, Shigeo Kitayama, Yoshizo Matsuka, Glenn T Clark, Takuo Kuboki |
Journal | Journal of prosthodontic research
(J Prosthodont Res)
Vol. 58
Issue 4
Pg. 217-22
(Oct 2014)
ISSN: 2212-4632 [Electronic] Japan |
PMID | 25127373
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Serotonin Plasma Membrane Transport Proteins
- Serotonin
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Topics |
- Adult
- Blood Platelets
(metabolism)
- Electromyography
- Female
- Humans
- Male
- Platelet Count
- Serotonergic Neurons
(metabolism)
- Serotonin
(blood)
- Serotonin Plasma Membrane Transport Proteins
(blood, metabolism)
- Severity of Illness Index
- Sleep Bruxism
(blood, diagnosis, metabolism)
- Young Adult
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