Validation of pH dataloggers for pharmacologic studies.

Abstract

Twenty-four-hour gastric aspiration studies have been superseded by dataloggers that continuously record intragastric pH. We have studied both techniques in a practical pharmacologic study, comparing early evening versus nighttime dosing with ranitidine and nizatidine against placebo. Whereas there was a highly significant point correlation between aspiration and datalogger pH, the slope was significantly less than 1. The correlation was poorer during the day (r = 0.51) than at night (r = 0.83). Irrespective of the techniques used, however, conclusions reached on drug efficacy were similar, but direct comparison of data from the two techniques is not possible.

• Authors: S G Chiverton, D W Burget, R H Hunt
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 24 Issue 8 Pg. 975-81 (Oct 1989) ISSN: 0036-5521 [Print] England
• PMID: 2512632 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Thiazoles
• Ranitidine
• Nizatidine

Topics

• Circadian Rhythm
• Clinical Trials as Topic
• Double-Blind Method
• Electronic Data Processing
• Gastric Acid (metabolism)
• Gastric Acidity Determination
• Humans
• Hydrogen-Ion Concentration
• Nizatidine
• Random Allocation
• Ranitidine (pharmacology)
• Thiazoles (pharmacology)
• Time Factors